Analysis of the Interaction between Traumatic Brain Injury and Mild Behavioral

 
   Lead Investigator:    Matthew Peters
   Institution      :    Johns Hopkins
   E-Mail           :    matthew.peters@jhmi.edu
   Proposal ID      :    893



   Proposal Description:
   Here we aim to examine the interaction between traumatic brain injury (TBI) and   mild behavioral impairment (MBI) (as measured by the NPI) and the influence on    progression from cognitively normal to mild cognitive impairment / Alzheimer's    dementia. A secondary objective is to look at how TBI influences neuropathology   and whether location of neuropathology influences MBI. The expected outcome is    that more individuals with TBI will have MBI and that individuals MBI is          predictive of progression from cognitively normal to MCI/AD.                      1. To test the hypothesis that TBI is a risk factor for MBI.                      2. To test the hypothesis that MBI (and potentially an interaction with TBI) is   predictive of progression from cognitively normal to MCI/AD.                      3. To test the hypothesis that individuals with TBI / MBI have a different        pattern of neuropathology.                                                        4. To examine the influence of APOE genotype